B-12 in our food supply is estimated to be 78% less than in the 1960s. Diet alone is hard pressed to provide the necessary levels of this important ent. In addition, stress and reduced hydrochloric (HCl) and intrinsic factor production in the stomach impair absorption. The most commonly used forms of B-12 require activation in the body, making uptake quite low - rarely more than 50%.* Perque delivers B-12 in its superior, activated hydroxocobalamin form. Hydroxocobalamin lasts longer and raises B-12 blood concentrations higher than other forms. Hydroxocobalamin requires no intrinsic factor and is taken up directly by mucous membranes regardless of digestive competence.* Hydroxocobalamin is easily converted to active but short-lived methylcobalamin and adenosylcobalamin as needed in the body. Hydroxocobalamin, the parent to other B-12 forms, provides better, long-lived B-12 action in the body. Perque Activated B-12 Guard is one of the supplements included in the Simplified Methylation Protocol for chronic igue syndrome (ME/CFS) and fibromyalgia that was developed by Drs. Neil Nathan, MD; Rich Van Konynenburg, PhD; Amy Yasko, PhD; and Jacob Teitelbaum, MD. This group of supplements ( FolaPro , ActiFolate , Perque Activated B-12 Guard, and Neurological Formula ) has been selected and formulated to provide ents that the body needs to support normal methylation - a process that is critical for a host of the body's most important reactions, from creation of glutathione (the body's 'master' antioxidant and detoxifier) to energy generation, repair, and serotonin production. See " A Simplified Methylation Protocol is Effective for the of Chronic igue Syndrome and Fibromyalgia " by Neil Nathan, MD.
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